β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians
D Yabe, Y Seino, M Fukushima, S Seino - Current diabetes reports, 2015 - Springer
Abstract Type 2 diabetes (T2DM) is one of the most serious global health problems and is
mainly a result of the drastic increase in East Asia, which includes over a fourth of the global …
mainly a result of the drastic increase in East Asia, which includes over a fourth of the global …
Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies
Aims/hypothesis We carried out a systematic review of clinical studies investigating
glucagon-like peptide-1 (GLP-1) secretion in patients with type 2 diabetes and non-diabetic …
glucagon-like peptide-1 (GLP-1) secretion in patients with type 2 diabetes and non-diabetic …
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
M Nagashima, T Watanabe, M Terasaki, M Tomoyasu… - Diabetologia, 2011 - Springer
Aims/hypothesis Several lines of evidence suggest that incretin-based therapies suppress
the development of cardiovascular disease in type 2 diabetes. We investigated the …
the development of cardiovascular disease in type 2 diabetes. We investigated the …
Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies
OBJECTIVE To investigate glucose-dependent insulinotropic polypeptide (GIP) secretion in
patients with type 2 diabetes and nondiabetic control subjects during oral glucose or meal …
patients with type 2 diabetes and nondiabetic control subjects during oral glucose or meal …
[HTML][HTML] Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
According to World Health Organization estimates, type 2 diabetes (T2D) is an epidemic
(particularly in under development countries) and a socio-economic challenge. This is even …
(particularly in under development countries) and a socio-economic challenge. This is even …
A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atherosclerosis
Y Tashiro, K Sato, T Watanabe, K Nohtomi, M Terasaki… - Peptides, 2014 - Elsevier
Macrophage foam cell formation, characterized by cholesterol ester accumulation catalyzed
by acyl-CoA: cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis …
by acyl-CoA: cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis …
What is GLP-1 really doing in obesity?
T Hira, J Pinyo, H Hara - Trends in Endocrinology & Metabolism, 2020 - cell.com
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released in response to meal
ingestion and enhances insulin secretion from pancreatic β cells. In several human studies …
ingestion and enhances insulin secretion from pancreatic β cells. In several human studies …
[HTML][HTML] The function of gastrointestinal hormones in obesity—implications for the regulation of energy intake
M Farhadipour, I Depoortere - Nutrients, 2021 - mdpi.com
The global burden of obesity and the challenges of prevention prompted researchers to
investigate the mechanisms that control food intake. Food ingestion triggers several …
investigate the mechanisms that control food intake. Food ingestion triggers several …
Dipeptidyl peptidase-4 inhibitors: Novel mechanism of actions
AK Singh - Indian journal of endocrinology and metabolism, 2014 - journals.lww.com
The pharmacological actions of the glucagon-like peptide-1 receptor agonists (GLP-1RA)
are largely predictable as they interact directly with GLP-1 receptors on beta cells to mediate …
are largely predictable as they interact directly with GLP-1 receptors on beta cells to mediate …
Gip as a potential therapeutic target for atherosclerotic cardiovascular disease–a systematic review
Y Mori, T Matsui, T Hirano, S Yamagishi - International Journal of …, 2020 - mdpi.com
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
are gut hormones that are secreted from enteroendocrine L cells and K cells in response to …
are gut hormones that are secreted from enteroendocrine L cells and K cells in response to …