Lipids comprise a large group of chemically heterogeneous compounds. The majority have
fatty acids (FA) as part of their structure, making these compounds suitable tools to examine …

Liposomes hold great potential as gene and drug delivery vehicles due to their
biocompatibility and modular properties, coupled with the major advantage of attenuating …

Onpattro, the first RNAi-based therapeutic to receive FDA approval, is enabled by a lipid
nanoparticle (LNP) system that facilitates siRNA delivery into the cytoplasm of target cells …

Mammalian cell membranes are composed of a complex array of glycerophospholipids and
sphingolipids that vary in head-group and acyl-chain composition. In a given cell type …

Docosahexaenoic acid (DHA) with 22-carbons and 6 double bonds is the extreme example
of an ω-3 polyunsaturated fatty acid (PUFA). DHA has strong medical implications since its …

Without any exaggeration, cholesterol is one of the most important lipid species in eukaryotic
cells. Its effects on cellular membranes and functions range from purely mechanistic to …

GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).
It has six lysine residues that have been proposed to affect membrane binding. We …

Biochemical and cell-biological experiments have identified cholesterol as an important
component of lipid 'rafts' and related structures (eg, caveolae) in mammalian cell …

Carotenoids are a group of pigments present both in the plant and animal kingdoms, which
play several important physiological functions. The protection against active oxygen species …

The insolubility of lipids in detergents is a useful method for probing the structure of
biological membranes. Insolubility in detergents like Triton X-100 is observed in lipid …