Quorum sensing for population-level control of bacteria and potential therapeutic applications

S Wu, J Liu, C Liu, A Yang, J Qiao - Cellular and Molecular Life Sciences, 2020 - Springer
Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

Foundations for the design and implementation of synthetic genetic circuits

AL Slusarczyk, A Lin, R Weiss - Nature Reviews Genetics, 2012 - nature.com
Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …

[KIRJA][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops

A Pokhilko, AP Fernández, KD Edwards… - Molecular systems …, 2012 - embopress.org
Circadian clocks synchronise biological processes with the day/night cycle, using molecular
mechanisms that include interlocked, transcriptional feedback loops. Recent experiments …

Synthetic in vitro transcriptional oscillators

J Kim, E Winfree - Molecular systems biology, 2011 - embopress.org
The construction of synthetic biochemical circuits from simple components illuminates how
complex behaviors can arise in chemistry and builds a foundation for future biological …

Design and analysis of a proportional-integral-derivative controller with biological molecules

M Chevalier, M Gómez-Schiavon, AH Ng, H El-Samad - Cell systems, 2019 - cell.com
The capability to engineer de novo feedback control with biological molecules is ushering in
an era of robust functionality for many applications in biotechnology and medicine. To fulfill …

Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans

MWM Meeuse, YP Hauser… - Molecular Systems …, 2020 - embopress.org
Gene expression oscillators can structure biological events temporally and spatially.
Different biological functions benefit from distinct oscillator properties. Thus, finite …

From resonance to chaos by modulating spatiotemporal patterns through a synthetic optogenetic oscillator

JH Park, G Holló, Y Schaerli - Nature communications, 2024 - nature.com
Oscillations are a recurrent phenomenon in biological systems across scales, but
deciphering their fundamental principles is very challenging. Here, we tackle this challenge …

The intracellular dynamics of circadian clocks reach for the light of ecology and evolution

AJ Millar - Annual review of plant biology, 2016 - annualreviews.org
A major challenge for biology is to extend our understanding of molecular regulation from
the simplified conditions of the laboratory to ecologically relevant environments. Tractable …

Agent-based modelling in synthetic biology

TE Gorochowski - Essays in biochemistry, 2016 - portlandpress.com
Biological systems exhibit complex behaviours that emerge at many different levels of
organization. These span the regulation of gene expression within single cells to the use of …