Life with bacterial mechanosensitive channels, from discovery to physiology to pharmacological target

P Blount, I Iscla - Microbiology and Molecular Biology Reviews, 2020 - Am Soc Microbiol
General principles in biology have often been elucidated from the study of bacteria. This is
true for the bacterial mechanosensitive channel of large conductance, MscL, the channel …

Diphtheria in Europe: current problems and new challenges

K Zakikhany, A Efstratiou - Future microbiology, 2012 - Taylor & Francis
Diphtheria, caused by toxigenic strains of Corynebacterium diphtheriae, is an ancient
disease with high incidence and mortality that has always been characterized by epidemic …

Exoproteome and Secretome Derived Broad Spectrum Novel Drug and Vaccine Candidates in Vibrio cholerae Targeted by Piper betel Derived Compounds

D Barh, N Barve, K Gupta, S Chandra, N Jain, S Tiwari… - PloS one, 2013 - journals.plos.org
Vibrio cholerae is the causal organism of the cholera epidemic, which is mostly prevalent in
develo** and underdeveloped countries. However, incidences of cholera in developed …

Target-Pathogen: a structural bioinformatic approach to prioritize drug targets in pathogens

EJ Sosa, G Burguener, E Lanzarotti… - Nucleic acids …, 2018 - academic.oup.com
Available genomic data for pathogens has created new opportunities for drug discovery and
development to fight them, including new resistant and multiresistant strains. In particular …

Genome-Based Drug Target Identification in Human Pathogen Streptococcus gallolyticus

NA Qureshi, SM Bakhtiar, M Faheem, M Shah… - Frontiers in …, 2021 - frontiersin.org
Streptococcus gallolysticus (Sg) is an opportunistic Gram-positive, non-motile bacterium,
which causes infective endocarditis, an inflammation of the inner lining of the heart. As Sg …

An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach

A Kumar Jaiswal, S Tiwari, SB Jamal, D Barh… - International journal of …, 2017 - mdpi.com
Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and
parasites that are transmitted from one person to another primarily by vaginal, anal, or oral …

An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae

SB Jamal, SS Hassan, S Tiwari, MV Viana… - PLoS …, 2017 - journals.plos.org
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for
diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually …

A new antibiotic with potent activity targets MscL

I Iscla, R Wray, P Blount, J Larkins-Ford… - The Journal of …, 2015 - nature.com
The growing problem of antibiotic-resistant bacteria is a major threat to human health.
Paradoxically, new antibiotic discovery is declining, with most of the recently approved …

A web resource for designing subunit vaccine against major pathogenic species of bacteria

G Nagpal, SS Usmani, GPS Raghava - Frontiers in Immunology, 2018 - frontiersin.org
Evolution has led to the expansion of survival strategies in pathogens including bacteria and
emergence of drug resistant strains proved to be a major global threat. Vaccination is a …

[PDF][PDF] In silico approach for mining of potential drug targets from hypothetical proteins of bacterial proteome

UNM Omeershffudin, S Kumar - Int J Mol Biol Open Access, 2019 - researchgate.net
An increase in expansion of antibiotic-resistant bacterial pathogens alarms the world's
population and creating a wave of the antibiotic apocalypse. The inclination of the death rate …