Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention
owing to their potential in the field of organic synthesis and medicinal chemistry. During the …

Experience-dependent plasticity at excitatory synapses of the mesocorticolimbic system is a
fundamental brain mechanism that enables adaptation to an ever-changing environment …

Optimisation of oral bioavailability is a continuing challenge for the pharmaceutical and
biotechnology industries. The number of potential drug candidates requiring invivo …

An organocatalytic method for the modular synthesis of diverse N‐aryl and N‐alkyl
azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported …

This volume in the Chemistry of Heterocyclic Compounds series presents a comprehensive
review of the quinoxaline literature from 1975 to the present (2002), updating Volumes 5 and …

Besides worthy development in cancer therapy, cancer is still one of the leading causes of
death, worldwide. The future burden of cancer will probably be even larger because people …

Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central
nervous system (CNS) where it is involved in the physiological regulation of different …

The discovery of NMDA receptors (NMDARs) was made possible by the synthesis and study
of NMDA (Figure 12.1) and various NMDAR antagonists by Jeff Watkins and colleagues [1] …

Ce travail explore la synthèse de nouveaux dérivés basés sur l'échafaudage quinoxaline-2,
3-dione pour développer un nouveau dérivé de quinoxaline biologiquement actif. Ces …