Fuchs endothelial corneal dystrophy: The vicious cycle of Fuchs pathogenesis
Fuchs endothelial corneal dystrophy (FECD) is the most common primary corneal
endothelial dystrophy and the leading indication for corneal transplantation worldwide …
endothelial dystrophy and the leading indication for corneal transplantation worldwide …
Oxidative stress and reactive oxygen species: a review of their role in ocular disease
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …
[HTML][HTML] Current understanding of the pathogenesis of Fuchs' endothelial corneal dystrophy
GG Nanda, DP Alone - Molecular vision, 2019 - ncbi.nlm.nih.gov
Fuchs' endothelial corneal dystrophy (FECD) is the most prominent reason for corneal-
endothelial transplantations across the globe. The disease pathophysiology manifests …
endothelial transplantations across the globe. The disease pathophysiology manifests …
Diseases of the corneal endothelium
LJ Jeang, CE Margo, EM Espana - Experimental eye research, 2021 - Elsevier
The corneal endothelial monolayer and associated Descemet's membrane (DM) complex is
a unique structure that plays an essential role in corneal function. Endothelial cells are …
a unique structure that plays an essential role in corneal function. Endothelial cells are …
Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells
MD Wagoner, LR Bohrer, BT Aldrich… - Biology …, 2018 - journals.biologists.com
The purpose of this study was to devise a strategy for the derivation of corneal endothelial
cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs …
cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs …
[HTML][HTML] Mitochondrial ROS induced lysosomal dysfunction and autophagy impairment in an animal model of congenital hereditary endothelial dystrophy
Purpose: The Slc4a11 knock out (KO) mouse model recapitulates the human disease
phenotype associated with congenital hereditary endothelial dystrophy (CHED). Increased …
phenotype associated with congenital hereditary endothelial dystrophy (CHED). Increased …
Potential theranostic roles of SLC4 molecules in human diseases
J Zhong, J Dong, W Ruan, X Duan - International Journal of Molecular …, 2023 - mdpi.com
The solute carrier family 4 (SLC4) is an important protein responsible for the transport of
various ions across the cell membrane and mediating diverse physiological functions, such …
various ions across the cell membrane and mediating diverse physiological functions, such …
The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling
Solute-linked cotransporter, SLC4A11, a member of the bicarbonate transporter family, is an
electrogenic H+ transporter activated by NH3 and alkaline pH. Although SLC4A11 does not …
electrogenic H+ transporter activated by NH3 and alkaline pH. Although SLC4A11 does not …
[HTML][HTML] Ammonia sensitive SLC4A11 mitochondrial uncoupling reduces glutamine induced oxidative stress
Abstract SLC4A11 is a NH 3 sensitive membrane transporter with H+ channel-like properties
that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss …
that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss …
The molecular basis of fuchs' endothelial corneal dystrophy
Fuchs' endothelial corneal dystrophy (FECD) is a common disease resulting from corneal
endothelial cell dysfunction. It is inherited in an autosomal dominant fashion with incomplete …
endothelial cell dysfunction. It is inherited in an autosomal dominant fashion with incomplete …