Biomarkers in Parkinson's disease (recent update)
S Sharma, CS Moon, A Khogali, A Haidous… - Neurochemistry …, 2013 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder whose exact
causative mechanisms are still under intense investigation. Several lines of evidence …
causative mechanisms are still under intense investigation. Several lines of evidence …
Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer's disease
Background We investigated whether a panel of 12 potential novel biomarkers consisting of
proteins involved in synapse functioning and immunity would be able to distinguish patients …
proteins involved in synapse functioning and immunity would be able to distinguish patients …
Spatiotemporal proteomic profiling of Huntington's disease inclusions reveals widespread loss of protein function
Aggregation of polyglutamine-expanded huntingtin exon 1 (HttEx1) in Huntington's disease
(HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates …
(HD) proceeds from soluble oligomers to late-stage inclusions. The nature of the aggregates …
Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro
D van Straten, H Sork, L van de Schepop… - Journal of Controlled …, 2024 - Elsevier
Lipid nanoparticles (LNPs) have successfully entered the clinic for the delivery of mRNA-and
siRNA-based therapeutics, most recently as vaccines for COVID-19. Nevertheless, there is a …
siRNA-based therapeutics, most recently as vaccines for COVID-19. Nevertheless, there is a …
Fungal infection in patients with Alzheimer's disease
R Alonso, D Pisa, AI Marina, E Morato… - Journal of …, 2014 - content.iospress.com
Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia
mainly among the elderly. This disease is characterized by the presence in the brain of …
mainly among the elderly. This disease is characterized by the presence in the brain of …
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
In this study, the human cerebrospinal fluid (CSF) proteome was mapped using three
different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode …
different strategies prior to Orbitrap LC-MS/MS analysis: SDS-PAGE and mixed mode …
Recent advances in quantitative neuroproteomics
GE Craft, A Chen, AC Nairn - Methods, 2013 - Elsevier
The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …
including improvements in mass spectrometric platforms, peptide identification algorithms …
Optical nanosensor for intracellular and intracranial detection of amyloid-beta
Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer's disease (AD), but the
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …
Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomics
KR Wildsmith, SP Schauer, AM Smith, D Arnott… - Molecular …, 2014 - Springer
Background Alzheimer's disease (AD) is the leading cause of dementia affecting greater
than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ 42, tau …
than 26 million people worldwide. Although cerebrospinal fluid (CSF) levels of Aβ 42, tau …