Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity. However, scRNA-seq requires lysing cells, which impedes further …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic
opportunities, we performed comprehensive proteogenomic characterization of 110 tumors …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Natural mitochondrial DNA (mtDNA) mutations enable the inference of clonal relationships
among cells. mtDNA can be profiled along with measures of cell state, but has not yet been …

The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …

Sex differences in brain structure and function are of substantial scientific interest because of
sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a …