Demethylation─ the other side of the mercury methylation coin: a critical review
T Barkay, B Gu - ACS Environmental Au, 2021 - ACS Publications
The public and environmental health consequences of mercury (Hg) methylation have
drawn much attention and considerable research to Hg methylation processes and their …
drawn much attention and considerable research to Hg methylation processes and their …
Expanded Diversity and Phylogeny of mer Genes Broadens Mercury Resistance Paradigms and Reveals an Origin for MerA Among Thermophilic Archaea
Mercury (Hg) is a highly toxic element due to its high affinity for protein sulfhydryl groups,
which upon binding, can destabilize protein structure and decrease enzyme activity …
which upon binding, can destabilize protein structure and decrease enzyme activity …
Shining light on recent advances in microbial mercury cycling
Mercury (Hg) is a global pollutant emitted primarily as gaseous Hg0 that is deposited in
aquatic and terrestrial ecosystems following its oxidation to HgII. From that point, microbes …
aquatic and terrestrial ecosystems following its oxidation to HgII. From that point, microbes …
Organomercurial lyase (MerB)-mediated demethylation decreases bacterial methylmercury resistance in the absence of mercuric reductase (MerA)
IN Krout, T Scrimale, D Vorojeikina… - Applied and …, 2022 - Am Soc Microbiol
The mer operon encodes enzymes that transform and detoxify methylmercury (MeHg) and/or
inorganic mercury [Hg (II)]. Organomercurial lyase (MerB) and mercuric reductase (MerA) …
inorganic mercury [Hg (II)]. Organomercurial lyase (MerB) and mercuric reductase (MerA) …
Eight Unexpected Selenoprotein Families in Organometallic Biochemistry in Clostridium difficile, in ABC Transport, and in Methylmercury Biosynthesis
DH Haft, M Gwadz - Journal of Bacteriology, 2023 - Am Soc Microbiol
The bioinformatics of a nine-gene locus, designated selenocysteine-assisted organometallic
(SAO), was investigated after identifying six new selenoprotein families and constructing …
(SAO), was investigated after identifying six new selenoprotein families and constructing …
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype
We present a potential mechanism for emergence of catalytic activity that is essential for
survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of …
survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of …
Screening of mercury‐resistant and indole‐3‐acetic acid producing bacterial‐consortium for growth promotion of Cicer arietinum L.
Mercury resistant (HgR) bacteria were screened from industrial effluents and effluents‐
polluted rhizosphere soils near to districts Kasur and Sheikhupura, Pakistan. Out of 60 …
polluted rhizosphere soils near to districts Kasur and Sheikhupura, Pakistan. Out of 60 …
Structural and biochemical characterization of organotin and organolead compounds binding to the organomercurial lyase MerB provide new insights into its …
The organomercurial lyase MerB has the unique ability to cleave carbon–Hg bonds, and
structural studies indicate that three residues in the active site (C96, D99, and C159 in E. coli …
structural studies indicate that three residues in the active site (C96, D99, and C159 in E. coli …
Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa
Y Guo, W Deng, Q Mo, Y Yu, Z Zhang, M Wei… - Microbiology …, 2025 - journals.asm.org
Mercury pollution is a kind of heavy metal pollution with great harm and strong toxicity which
exists worldwide. Some microorganisms can convert highly toxic methylmercury into …
exists worldwide. Some microorganisms can convert highly toxic methylmercury into …
Hg–C bond protonolysis by a functional model of bacterial enzyme organomercurial lyase MerB
Herein, we report a novel synthetic compound 1, having a highly nucleophilic selenolate
(Se−) moiety and a thiol (–SH) functional group, which showed efficient Hg–C bond …
(Se−) moiety and a thiol (–SH) functional group, which showed efficient Hg–C bond …