Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Y Esmaeili, Z Yarjanli, F Pakniya, E Bidram… - Journal of Controlled …, 2022 - Elsevier
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

Artificial intelligence in early drug discovery enabling precision medicine

F Boniolo, E Dorigatti, AJ Ohnmacht… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Precision medicine is the concept of treating diseases based on environmental
factors, lifestyles, and molecular profiles of patients. This approach has been found to …

[HTML][HTML] Envisioning the future of personalized medicine: Role and realities of digital twins

A Vallée - Journal of Medical Internet Research, 2024 - jmir.org
Digital twins have emerged as a groundbreaking concept in personalized medicine, offering
immense potential to transform health care delivery and improve patient outcomes. It is …

Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration

R Tenchov, JM Sasso, QA Zhou - ACS Chemical Neuroscience, 2024 - ACS Publications
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders
caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with …

[PDF][PDF] Big data analytics in healthcare: a review of recent advances and potential for personalized medicine

A Obijuru, JO Arowoogun, C Onwumere… - International Medical …, 2024 - researchgate.net
BIG DATA ANALYTICS IN HEALTHCARE: A REVIEW OF RECENT ADVANCES AND
POTENTIAL FOR PERSONALIZED MEDICINE Page 1 International Medical Science …

Angiotensin system polymorphisms' in SARS-CoV-2 positive patients: assessment between symptomatic and asymptomatic patients: a pilot study

C Cafiero, F Rosapepe, R Palmirotta, A Re… - Pharmacogenomics …, 2021 - Taylor & Francis
Introduction The renin–angiotensin–aldosterone system (RAAS), a metabolic cascade
regulating pressure and circulating blood volume, has been considered the main system …

[HTML][HTML] Optimizing and accelerating the development of precision pain treatments for chronic pain: IMMPACT review and recommendations

RR Edwards, KL Schreiber, RH Dworkin, DC Turk… - The journal of pain, 2023 - Elsevier
Large variability in the individual response to even the most-efficacious pain treatments is
observed clinically, which has led to calls for a more personalized, tailored approach to …

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

C Bouquerel, A Dubrova, I Hofer, DTT Phan… - Lab on a Chip, 2023 - pubs.rsc.org
Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …

[HTML][HTML] Clinical perspectives of gut microbiota in patients with chronic kidney disease and end-stage kidney disease: where do we stand?

AC Pantazi, MAK Kassim, W Nori, LA Tuta, CM Mihai… - Biomedicines, 2023 - mdpi.com
The gut microbiota (GM) plays a vital role in human health, with increasing evidence linking
its imbalance to chronic kidney disease and end-stage kidney disease. Although the exact …

[PDF][PDF] Epigenetics in neurological and psychiatric disorders: a comprehensive review of current understanding and future perspectives

H Grezenko, C Ekhator, NU Nwabugwu, H Ganga… - Cureus, 2023 - cureus.com
The burgeoning field of epigenetics offers transformative insights into the complex
landscape of neurological and psychiatric disorders. By unraveling the intricate interplay …