Artificial intelligence for drug toxicity and safety

AO Basile, A Yahi, NP Tatonetti - Trends in pharmacological sciences, 2019 - cell.com
Interventional pharmacology is one of medicine's most potent weapons against disease.
These drugs, however, can result in damaging side effects and must be closely monitored …

Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery

MK Tripathi, A Nath, TP Singh, AS Ethayathulla… - Molecular Diversity, 2021 - Springer
The accumulation of massive data in the plethora of Cheminformatics databases has made
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …

An introduction to machine learning and analysis of its use in rheumatic diseases

KM Kingsmore, CE Puglisi, AC Grammer… - Nature Reviews …, 2021 - nature.com
Abstract Machine learning (ML) is a computerized analytical technique that is being
increasingly employed in biomedicine. ML often provides an advantage over explicitly …

Drug targets for COVID-19 therapeutics: Ongoing global efforts

A Saxena - Journal of biosciences, 2020 - Springer
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already
inflicted insurmountable damage both to the human lives and global economy. There is an …

Applications of artificial intelligence in drug development using real-world data

Z Chen, X Liu, W Hogan, E Shenkman, J Bian - Drug discovery today, 2021 - Elsevier
Highlights•Artificial intelligence (AI) and real-world data (RWD) are increasing used in drug
development.•Adverse event detection, trial recruitment, and drug repurposing are the most …

Pathway-based drug-repurposing schemes in cancer: the role of translational bioinformatics

E Hernández-Lemus, M Martínez-García - Frontiers in Oncology, 2021 - frontiersin.org
Cancer is a set of complex pathologies that has been recognized as a major public health
problem worldwide for decades. A myriad of therapeutic strategies is indeed available …

An analytical review of computational drug repurposing

SS Sadeghi, MR Keyvanpour - IEEE/ACM transactions on …, 2019 - ieeexplore.ieee.org
Drug repurposing is a vital function in pharmaceutical fields and has gained popularity in
recent years in both the pharmaceutical industry and research community. It refers to the …

Framework for identifying drug repurposing candidates from observational healthcare data

M Ozery-Flato, Y Goldschmidt, O Shaham, S Ravid… - Jamia …, 2020 - academic.oup.com
Objective Observational medical databases, such as electronic health records and
insurance claims, track the healthcare trajectory of millions of individuals. These databases …

Modern computational intelligence based drug repurposing for diabetes epidemic

S Mohanty, MH Al Rashid, C Mohanty… - Diabetes & Metabolic …, 2021 - Elsevier
Background and aim Objectives are to explore recent advances in discovery of new
antidiabetic agents using repurposing strategies and to discuss modern technologies used …

The use of real-world data in drug repurposing

K Park - Translational and Clinical Pharmacology, 2021 - pmc.ncbi.nlm.nih.gov
Drug repurposing, or repositioning, is to identify new uses for existing drugs. Significantly
reducing the costs and time-to-market of a medication, drug repurposing has been an …