Genomic methods in profiling DNA accessibility and factor localization
Recent advancements in next-generation sequencing technologies and accompanying
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …
Tracing the origin of cell-Free DNA molecules through tissue-Specific epigenetic signatures
All cell and tissue types constantly release DNA fragments into human body fluids by various
mechanisms including programmed cell death, accidental cell degradation and active …
mechanisms including programmed cell death, accidental cell degradation and active …
TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV
Abstract The Human Silencing Hub (HUSH) complex constituted of TASOR, MPP8 and
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
Periphilin recruits the histone methyl-transferase SETDB1 to spread H3K9me3 repressive …
Large-scale DNA demethylation occurs in proliferating ovarian granulosa cells during mouse follicular development
T Kawai, JAS Richards, M Shimada - Communications Biology, 2021 - nature.com
During ovarian follicular development, granulosa cells proliferate and progressively
differentiate to support oocyte maturation and ovulation. To determine the underlying links …
differentiate to support oocyte maturation and ovulation. To determine the underlying links …
[HTML][HTML] SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex
H Shen, T He, S Wang, L Hou, Y Wei, Y Liu, C Mo… - Theranostics, 2022 - ncbi.nlm.nih.gov
Brown and beige fat protect against cold environments and obesity by catabolizing stored
energy to generate heat. This process is achieved by controlling thermogenesis-related …
energy to generate heat. This process is achieved by controlling thermogenesis-related …
ZBTB48 is a priming factor regulating B-cell-specific CIITA expression
G Rane, VLS Kuan, S Wang, MMH Mok… - The EMBO …, 2024 - embopress.org
The class-II transactivator (CIITA) is the master regulator of MHC class-II gene expression
and hence the adaptive immune response. Three cell type-specific promoters (pI, pIII, and …
and hence the adaptive immune response. Three cell type-specific promoters (pI, pIII, and …
Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner
SS Weiterer, J Meier‐Soelch, T Georgomanolis… - The EMBO …, 2020 - embopress.org
How cytokine‐driven changes in chromatin topology are converted into gene regulatory
circuits during inflammation still remains unclear. Here, we show that interleukin (IL)‐1α …
circuits during inflammation still remains unclear. Here, we show that interleukin (IL)‐1α …
The proinflammatory cytokine TNFα induces DNA demethylation–dependent and–independent activation of interleukin-32 expression
IL-32 is a cytokine involved in proinflammatory immune responses to bacterial and viral
infections. However, the role of epigenetic events in the regulation of IL-32 gene expression …
infections. However, the role of epigenetic events in the regulation of IL-32 gene expression …
Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription
F Bejjani, E Evanno, S Mahfoud, C Tolza, K Zibara… - Cell & Bioscience, 2023 - Springer
Abstract Background How transcription factors (TFs) down-regulate gene expression
remains ill-understood, especially when they bind to multiple enhancers contacting the …
remains ill-understood, especially when they bind to multiple enhancers contacting the …
Genome-wide analysis unveils DNA helicase RECQ1 as a regulator of estrogen response pathway in breast cancer cells
Susceptibility to breast cancer is significantly increased in individuals with germ line
mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase …
mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase …