The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Background Studies using positron emission tomography to image striatal dopamine
function, have demonstrated that individuals with schizophrenia display increases in …

Context Current drug treatments for schizophrenia are inadequate for many patients, and
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …

In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

To the Editor: Approximately a third of patients with schizophrenia show a limited response
to antipsychotic medication (1). This might be due to distinct neurochemical abnormalities in …