Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …
regulatory domains of target proteins, which control a protein's stability. These regions …
Pathway Commons 2019 Update: integration, analysis and exploration of pathway data
Abstract Pathway Commons (https://www. pathwaycommons. org) is an integrated resource
of publicly available information about biological pathways including biochemical reactions …
of publicly available information about biological pathways including biochemical reactions …
Posttranslational Modifications of α-Synuclein, Their Therapeutic Potential, and Crosstalk in Health and Neurodegenerative Diseases
ABSTRACT α-Synuclein (α-Syn) aggregation in Lewy bodies and Lewy neurites has
emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies …
emerged as a key pathogenetic feature in Parkinson's disease, dementia with Lewy bodies …
qPTM: an updated database for PTM dynamics in human, mouse, rat and yeast
K Yu, Y Wang, Y Zheng, Z Liu, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …
protein functions temporally and spatially in various organisms. Since most PTMs are …
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis
H Li, C Li, B Zhang, H Jiang - Journal of Translational Medicine, 2023 - Springer
Background Although the relationship between type 2 diabetes (T2D) and the increased risk
of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods …
of colorectal carcinogenesis is widely defined in clinical studies, the therapeutic methods …
Unraveling the battle for lysine: A review of the competition among post-translational modifications
Proteins play a critical role as key regulators in various biological systems, influencing
crucial processes such as gene expression, cell cycle progression, and cellular proliferation …
crucial processes such as gene expression, cell cycle progression, and cellular proliferation …
Clinically relevant post-translational modification analyses—maturing workflows and bioinformatics tools
Post-translational modifications (PTMs) can occur soon after translation or at any stage in
the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular …
the lifecycle of a given protein, and they may help regulate protein folding, stability, cellular …
Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer
We analyzed large-scale post-translational modification (PTM) data to outline cell signaling
pathways affected by tyrosine kinase inhibitors (TKIs) in ten lung cancer cell lines. Tyrosine …
pathways affected by tyrosine kinase inhibitors (TKIs) in ten lung cancer cell lines. Tyrosine …
The human melanoma proteome atlas—Complementing the melanoma transcriptome
The MM500 meta‐study aims to establish a knowledge basis of the tumor proteome to serve
as a complement to genome and transcriptome studies. Somatic mutations and their effect …
as a complement to genome and transcriptome studies. Somatic mutations and their effect …
Counterion optimization dramatically improves selectivity for phosphopeptides and glycopeptides in electrostatic repulsion-hydrophilic interaction chromatography
A well-hydrated counterion can selectively and dramatically increase retention of a charged
analyte in hydrophilic interaction chromatography. The effect is enhanced if the column is …
analyte in hydrophilic interaction chromatography. The effect is enhanced if the column is …