The role of mitochondria in inflammation: from cancer to neurodegenerative disorders
The main features that are commonly attributed to mitochondria consist of the regulation of
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
cell proliferation, ATP generation, cell death and metabolism. However, recent scientific …
Endoplasmic reticulum stress: an arising target for metal-based anticancer agents
AP King, JJ Wilson - Chemical Society Reviews, 2020 - pubs.rsc.org
The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …
Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours
Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …
Mitochondria-associated membranes (MAMs) and inflammation
The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …
The regulation of autophagy by calcium signals: Do we have a consensus?
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …
Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer
S Romero-Garcia… - … journal of oncology, 2019 - spandidos-publications.com
In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …
cellular calcium management. The present review provides an integrative view of cellular …
The role of mitochondria-associated membranes in cellular homeostasis and diseases
Mitochondria and endoplasmic reticulum (ER) are fundamental in the control of cell
physiology regulating several signal transduction pathways. They continuously …
physiology regulating several signal transduction pathways. They continuously …
The roles of endoplasmic reticulum in NLRP3 inflammasome activation
Y Zhou, Z Tong, S Jiang, W Zheng, J Zhao, X Zhou - Cells, 2020 - mdpi.com
The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …
containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and …
Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury
Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …
ischemic heart disease holds the most considerable position. Even if it has been deeply …
[HTML][HTML] CISD2 maintains cellular homeostasis
ZQ Shen, YL Huang, YC Teng, TW Wang… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract CDGSH Iron Sulfur Domain 2 (CISD2) is the causative gene for the disease
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …
Wolfram syndrome 2 (WFS2; MIM 604928), which is an autosomal recessive disorder …