The cellular activity underlying human focal seizures, and its relationship to key signatures
in the EEG recordings used for therapeutic purposes, has not been well characterized …

We analyze the role of inhibition in sustaining focal epileptic seizure activity. We review
ongoing seizure activity at the mesoscopic scale that can be observed with microelectrode …

During human seizures, organized waves of voltage activity rapidly sweep across the cortex.
Two contradictory theories describe the source of these fast traveling waves: either a slowly …

Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment
(adjustment of their frequency to match the input frequency) is thought to support many …

The electrographic manifestation of neural activity can reflect the relationship between the
faster action potentials of individual neurons and the slower fluctuations of the local field …

The relationship between action potentials and the associated local field potential (LFP) in
neural recordings is typically studied only in the temporal domain using the spike-triggered …

Epilepsy is a disease affecting millions of people worldwide. Despite over 50 years of
research, the mechanisms that generate and sustain ictal discharges, a key neural hallmark …

Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures that
produce a distinct signature of hypersynchronous neural activity in electroencephalographic …

Brain function is reflected in both the action potentials of individual neurons and interactions
through eg synaptic currents reflected in widespread, slow fluctuations of the local field …