Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they
are formed, how they divide to self-renew, and how these processes are genetically …

The nm23 gene, a putative metastasis suppressor gene, was originally identified by its
reduced expression in highly metastatic K‐1735 murine melanoma cell lines, as compared …

Tumor suppressor genes have a pivotal role in normal cells regulating cell cycle processes
negatively. Furthermore, the inhibition of cell proliferation is a crucial step in the …

The human gene, human giant larvae (Hugl-1/Llg1/Lgl1) has significant homology to the
Drosophila tumour suppressor gene lethal (2) giant larvae (lgl). The lgl gene codes for a …

The proteins encoded by two groups of conserved genes, the Polycomb and trithorax
groups, have been proposed to maintain, at the level of chromatin structure, the expression …

Abstract The human gene Hugl-1 (Llgl/Lgl1) has significant homology to the Drosophila
tumor suppressor gene lethal (2) giant larvae (lgl). The lgl gene codes for a cortical …

Nucleoside diphosphate kinase (NDK), an enzyme encoded by the Drosophila abnormal
wing discs (awd) or human nm23 tumor suppressor genes, generates nucleoside …

Drosophila lethal giant larvae (lgl), discs large (dlg) and scribble (scrib) are tumour
suppressor genes acting in a common pathway, whose loss of function leads to disruption of …

Cell polarity is a fundamental property used to generate asymmetry and structure in all cells.
Cancer is associated with loss of cell and tissue structure. While observations made in …

More than 50 genes have been identified in Drosophila by loss-of-function mutations that
lead to overgrowth of specific tissues. Loss-of-function mutations in the lethal giant larvae …