Lipopolysaccharide (LPS) is a crucial constituent of the outer membrane of most Gram-
negative bacteria, playing a fundamental role in the protection of bacteria from …

Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

We present a new approach for macromolecular structure determination from multiple
particles in electron cryo-tomography (cryo-ET) data sets. Whereas existing subtomogram …

In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Nuclear magnetic resonance (NMR) spectroscopy is a well-established method for
analyzing protein structure, interaction, and dynamics at atomic resolution and in various …

Nitrosopumilus maritimus is an ammonia-oxidizing archaeon that is crucial to the global
nitrogen cycle,. A critical step for nitrogen oxidation is the entrapment of ammonium ions …

β Barrel outer membrane proteins (OMPs) cluster into supramolecular assemblies that give
function to the outer membrane (OM) of Gram-negative bacteria. How such assemblies form …

Lipopolysaccharides are critical components of bacterial outer membranes. The more
conserved lipid A part of the lipopolysaccharide molecule is a major element in the …

Cryo-electron tomography and subtomogram averaging (STA) has developed rapidly in
recent years. It provides structures of macromolecular complexes in situ and in cellular …

Ordered two-dimensional arrays such as S-layers, and designed analogues,–have intrigued
bioengineers,, but with the exception of a single lattice formed with flexible linkers, they are …