An overview of technical considerations for Western blotting applications to physiological research

JJ Bass, DJ Wilkinson, D Rankin… - … journal of medicine …, 2017 - Wiley Online Library
The applications of Western/immunoblotting (WB) techniques have reached multiple layers
of the scientific community and are now considered routine procedures in the field of …

The central dogma decentralized: new perspectives on RNA function and local translation in neurons

CE Holt, EM Schuman - Neuron, 2013 - cell.com
The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …

[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses

AK Banerjee, MR Blanco, EA Bruce, DD Honson… - Cell, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury

Z Álvarez, AN Kolberg-Edelbrock, IR Sasselli… - Science, 2021 - science.org
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be
effective in the regeneration of tissues. Here, we describe peptide amphiphile …

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

MV Lourenco, RL Frozza, GB de Freitas, H Zhang… - Nature medicine, 2019 - nature.com
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

R Su, L Dong, Y Li, M Gao, PC He, W Liu, J Wei… - Nature cell …, 2022 - nature.com
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

X Guo, G Aviles, Y Liu, R Tian, BA Unger, YHT Lin… - Nature, 2020 - nature.com
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in
which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the …

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

Z Dai, H Liu, J Liao, C Huang, X Ren, W Zhu, S Zhu… - Molecular cell, 2021 - cell.com
Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function

T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees… - Neuron, 2015 - cell.com
The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS
and FTD remain controversial. We propose a model in which low-complexity (LC) domains …