An overview of technical considerations for Western blotting applications to physiological research
The applications of Western/immunoblotting (WB) techniques have reached multiple layers
of the scientific community and are now considered routine procedures in the field of …
of the scientific community and are now considered routine procedures in the field of …
The central dogma decentralized: new perspectives on RNA function and local translation in neurons
The elaborate morphology of neurons together with the information processing that occurs in
remote dendritic and axonal compartments makes the use of decentralized cell biological …
remote dendritic and axonal compartments makes the use of decentralized cell biological …
[HTML][HTML] SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury
The signaling of cells by scaffolds of synthetic molecules that mimic proteins is known to be
effective in the regeneration of tissues. Here, we describe peptide amphiphile …
effective in the regeneration of tissues. Here, we describe peptide amphiphile …
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …
Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway
In mammalian cells, mitochondrial dysfunction triggers the integrated stress response, in
which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the …
which the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) results in the …
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression
Z Dai, H Liu, J Liao, C Huang, X Ren, W Zhu, S Zhu… - Molecular cell, 2021 - cell.com
Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …
cancer survival and progression, but the underlying mechanisms are poorly understood …
ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function
The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS
and FTD remain controversial. We propose a model in which low-complexity (LC) domains …
and FTD remain controversial. We propose a model in which low-complexity (LC) domains …