GPX4 in cell death, autophagy, and disease
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …
Ferroptosis in immunostimulation and immunosuppression
Ferroptosis is a form of iron‐dependent regulated cell death characterized by the
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
accumulation of toxic lipid peroxides, particularly in the plasma membrane, leading to lytic …
Oxidative stress in healthy and pathological red blood cells
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …
affect the structure, function, or production of red blood cells (RBCs). These disorders can …
Ferroptosis, a new pathogenetic mechanism in cardiometabolic diseases and cancer: Is there a role for statin therapy?
One of the newly recognized types of cell death is ferroptosis which is related to the
accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a …
accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a …
Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience
J Lee, JL Roh - Cancer Letters, 2023 - Elsevier
Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …
Iron brain menace: the involvement of ferroptosis in Parkinson disease
KJ Lin, SD Chen, KL Lin, CW Liou, MY Lan… - Cells, 2022 - mdpi.com
Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …
playing a dual role, since they can be either deleterious or beneficial to biological systems …
Discovery of a potent chloroacetamide GPX4 inhibitor with bioavailability to enable target engagement in mice, a potential tool compound for inducing ferroptosis in …
JT Randolph, MJ O'Connor, F Han… - Journal of Medicinal …, 2023 - ACS Publications
Compounds that inhibit glutathione peroxidase 4 (GPX4) hold promise as cancer
therapeutics in their ability to induce a form of nonapoptotic cell death called ferroptosis. Our …
therapeutics in their ability to induce a form of nonapoptotic cell death called ferroptosis. Our …
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription
Y Wang, J Feng, L Zhao, M Zhao, X Wei… - Acta Pharmacologica …, 2023 - nature.com
A number of studies have shown that aspirin, as commonly prescribed drug, prevents the
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …
Plant glutathione peroxidases: non-heme peroxidases with large functional flexibility as a core component of ROS-processing mechanisms and signalling
Glutathione peroxidases (GPXs) are non-heme peroxidases catalyzing the reduction of
H2O2 or organic hydroperoxides to water or corresponding alcohols using glutathione …
H2O2 or organic hydroperoxides to water or corresponding alcohols using glutathione …