Liver fibrosis is an abnormal wound repair response caused by a variety of chronic liver
injuries, which is characterized by over-deposition of diffuse extracellular matrix (ECM) and …

Hydrogel is a three-dimensional network polymer material rich in water. It is widely used in
the biomedical field because of its unique physical and chemical properties and good …

Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Inflammation underlies many chronic and degenerative diseases, but it also mitigates
infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link …

The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …

Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving
the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …

As an organ critically important for targeting and clearing viruses, bacteria, and other foreign
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …