Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal
vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The …

Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Curving biological membranes establishes the complex architecture of the cell and mediates
membrane traffic to control flux through subcellular compartments. Common molecular …

Clathrin-mediated endocytosis (CME) involves nanoscale bending and inward budding of
the plasma membrane, by which cells regulate both the distribution of membrane proteins …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

During clathrin-mediated endocytosis, dozens of proteins assemble into an interconnected
network at the plasma membrane. As initiators of endocytosis, Eps15 and Fcho1/2 …

Clathrin-mediated endocytosis is initiated by a network of weakly interacting proteins
through a poorly understood mechanism. Ede1, the yeast homolog of mammalian Eps15, is …

Force generation by actin assembly shapes cellular membranes. An experimentally
constrained multiscale model shows that a minimal branched actin network is sufficient to …