Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
underlying molecular pathologies have been identified, there is substantial heterogeneity in …
Map** neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
Brain connectomics: time for a molecular imaging perspective?
In the past two decades brain connectomics has evolved into a major concept in
neuroscience. However, the current perspective on brain connectivity and how it underpins …
neuroscience. However, the current perspective on brain connectivity and how it underpins …
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity
Alzheimer's disease (AD) is a heterogeneous disorder with abnormalities in multiple
biological domains. In an advanced machine learning analysis of postmortem brain and in …
biological domains. In an advanced machine learning analysis of postmortem brain and in …
Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease
Parkinson's disease involves multiple neurotransmitter systems beyond the classical
dopaminergic circuit, but their influence on structural and functional alterations is not well …
dopaminergic circuit, but their influence on structural and functional alterations is not well …
Macroscale connectome topographical structure reveals the biomechanisms of brain dysfunction in Alzheimer's disease
The intricate spatial configurations of brain networks offer essential insights into
understanding the specific patterns of brain abnormalities and the underlying biological …
understanding the specific patterns of brain abnormalities and the underlying biological …
Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …
Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical
models and human in vivo and post mortem studies. Understanding the consequences of …
models and human in vivo and post mortem studies. Understanding the consequences of …
The digital twin brain: A bridge between biological and artificial intelligence
In recent years, advances in neuroscience and artificial intelligence have paved the way for
unprecedented opportunities to understand the complexity of the brain and its emulation …
unprecedented opportunities to understand the complexity of the brain and its emulation …
[HTML][HTML] Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study
Background This international study aimed to characterise the impact of acute SARS-CoV-2
infection in people with cystic fibrosis and investigate factors associated with severe …
infection in people with cystic fibrosis and investigate factors associated with severe …