Metal Ion Signaling in Biomedicine
Complex multicellular organisms are composed of distinct tissues involving specialized cells
that can perform specific functions, making such life forms possible. Species are defined by …
that can perform specific functions, making such life forms possible. Species are defined by …
Psychotropic drugs for the management of chronic pain and itch
DA Belinskaia, MA Belinskaia, OI Barygin… - Pharmaceuticals, 2019 - mdpi.com
Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit
symptoms of increased anxiety, depression and cognitive impairment. Such patients need …
symptoms of increased anxiety, depression and cognitive impairment. Such patients need …
[HTML][HTML] Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons
Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential
vanilloid type 1 (TRPV1) agonists. TRPV1 overstimulation selectively ablates capsaicin …
vanilloid type 1 (TRPV1) agonists. TRPV1 overstimulation selectively ablates capsaicin …
Targeting breast cancer cells by MRS1477, a positive allosteric modulator of TRPV1 channels
There is convincing epidemiological and experimental evidence that capsaicin, a potent
natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has …
natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has …
Amitriptyline effectiveness in burning mouth syndrome: An in‐depth case series analysis
DR Gonçalves, LM Botelho, VC Carrard… - …, 2024 - Wiley Online Library
Objectives To assess the effectiveness of amitriptyline (AMT), and to identify the
determinants of the treatment's effectiveness in patients diagnosed with burning mouth …
determinants of the treatment's effectiveness in patients diagnosed with burning mouth …
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain
S Notartomaso, G Mascio, M Bernabucci… - Molecular …, 2017 - journals.sagepub.com
Background L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes
analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors …
analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors …
Human keratinocytes are vanilloid resistant
Background Use of capsaicin or resiniferatoxin (RTX) as analgesics is an attractive
therapeutic option. RTX opens the cation channel inflammatory pain/vanilloid receptor type …
therapeutic option. RTX opens the cation channel inflammatory pain/vanilloid receptor type …
Analgesic effects of topical amitriptyline in patients with chemotherapy-induced peripheral neuropathy: mechanistic insights from studies in mice
Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic
pain and is often associated with dose-limiting adverse events. We evaluated the potential …
pain and is often associated with dose-limiting adverse events. We evaluated the potential …
Resiniferatoxin mediated ablation of TRPV1+ neurons removes TRPA1 as well
Objectives: Resiniferatoxin, the most potent agonist of inflammatory pain/vanilloid
receptor/cation channel (TRPV1) can be used for neuron subtype specific ablation of pain …
receptor/cation channel (TRPV1) can be used for neuron subtype specific ablation of pain …
[HTML][HTML] Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations
Sensory neuron subpopulations as well as breast and prostate cancer cells express
functional transient receptor potential vanilloid type 1 (TRPV1) ion channels; however little is …
functional transient receptor potential vanilloid type 1 (TRPV1) ion channels; however little is …