Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways
The etiology of allergy is closely linked to type 2 inflammatory responses ultimately leading
to the production of allergen‐specific immunoglobulin E (IgE), a key driver of many allergic …
to the production of allergen‐specific immunoglobulin E (IgE), a key driver of many allergic …
Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell‐mediated diseases
Chronic urticaria (CU) is a mast cell (MC)‐dependent disease with limited therapeutic
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …
options. Current management strategies are directed at inhibiting IgE‐mediated activation of …
Gut microbiota facilitate chronic spontaneous urticaria
L Zhu, X Jian, B Zhou, R Liu, M Muñoz, W Sun… - Nature …, 2024 - nature.com
Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains
elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics …
elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics …
Controlled adsorption of multiple bioactive proteins enables targeted mast cell nanotherapy
Protein adsorption onto nanomaterials often results in denaturation and loss of bioactivity.
Controlling the adsorption process to maintain the protein structure and function has …
Controlling the adsorption process to maintain the protein structure and function has …
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria
Urticaria is a skin disorder characterized by outbreaks of raised pruritic wheals. In order to
identify sequence variants associated with urticaria, we performed a meta-analysis of …
identify sequence variants associated with urticaria, we performed a meta-analysis of …
Siglecs as potential targets of therapy in human mast cell-and/or eosinophil-associated diseases
Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …
Siglecs in allergy and asthma
BS Bochner, JA O'Sullivan, AT Chang… - Molecular aspects of …, 2023 - Elsevier
The term “allergic diseases” encompasses several common, IgE-mediated conditions that
range from being annoying to those that are life-threatening. Available treatments include …
range from being annoying to those that are life-threatening. Available treatments include …
Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
J Schanin, W Korver, EC Brock, J Leung… - Communications …, 2022 - nature.com
Mast cells (MC) are key drivers of allergic and inflammatory diseases. Sialic acid-binding
immunoglobulin-like lectin (Siglec)-6 is an immunoregulatory receptor found on MCs. While …
immunoglobulin-like lectin (Siglec)-6 is an immunoregulatory receptor found on MCs. While …
Human lung mast cells: therapeutic implications in asthma
Mast cells are strategically located in different compartments of the lung in asthmatic
patients. These cells are widely recognized as central effectors and immunomodulators in …
patients. These cells are widely recognized as central effectors and immunomodulators in …
A synthesis and subgroup analysis of the eosinophilic esophagitis tissue transcriptome
Background Eosinophilic esophagitis (EoE) is a chronic immune mediated inflammatory
disorder of the esophagus. It is still unknown why children and adults present differently, and …
disorder of the esophagus. It is still unknown why children and adults present differently, and …