Bioelectronics for electrical stimulation: materials, devices and biomedical applications

Y Huang, K Yao, Q Zhang, X Huang, Z Chen… - Chemical Society …, 2024 - pubs.rsc.org
Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of
advanced medical devices that interact with biological systems to effectively diagnose …

[HTML][HTML] Artificial intelligence for clinical trial design

S Harrer, P Shah, B Antony, J Hu - Trends in pharmacological sciences, 2019 - cell.com
Clinical trials consume the latter half of the 10 to 15 year, 1.5–2.0 billion USD, development
cycle for bringing a single new drug to market. Hence, a failed trial sinks not only the …

Retinal stimulation strategies to restore vision: Fundamentals and systems

L Yue, JD Weiland, B Roska, MS Humayun - Progress in retinal and eye …, 2016 - Elsevier
Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by
the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect …

[HTML][HTML] Nonsyndromic retinitis pigmentosa overview

AT Fahim, SP Daiger, RG Weleber - GeneReviews®[Internet], 2023 - ncbi.nlm.nih.gov
Retinitis pigmentosa (RP) refers to a group of inherited disorders in which abnormalities of
the photoreceptors (rods and cones) of the retina lead to progressive visual loss. RP is …

Precision electronic medicine in the brain

SR Patel, CM Lieber - Nature biotechnology, 2019 - nature.com
Periodically throughout history developments from adjacent fields of science and technology
reach a tip** point where together they produce unparalleled advances, such as the Allen …

Contemporary approaches to visual prostheses

RM Mirochnik, JS Pezaris - Military Medical Research, 2019 - Springer
Visual prostheses serve to restore visual function following acquired blindness. Acquired
blindness (as opposed to congenital blindness) has many causes, including diseases such …

Towards Pharma 4.0 in clinical trials: A future-orientated perspective

RE Hariry, RV Barenji, A Paradkar - Drug Discovery Today, 2022 - Elsevier
Abstract Pharma 4.0, a technology ecosystem in drug development analogous to Industry
4.0 in healthcare, is transforming the traditional approach to drug discovery and …

Residual vision activation and the brain-eye-vascular triad: Dysregulation, plasticity and restoration in low vision and blindness–a review

BA Sabel, J Flammer… - Restorative neurology and …, 2018 - content.iospress.com
Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular
degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the …

Polydopamine-doped conductive polymer microelectrodes for neural recording and stimulation

R Kim, Y Nam - Journal of Neuroscience Methods, 2019 - Elsevier
Background Microelectrodes have been widely used to detect and modulate the activities of
neuronal networks. Various materials have been applied to microelectrode fabrication, and …

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

NAL Chenais, MJIA Leccardi… - Journal of neural …, 2021 - iopscience.iop.org
Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light
called phosphenes, which allows them to perform visually guided tasks, such as orientation …