The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Trypanosomiases and leishmaniases are neglected tropical diseases that have been
spreading to previously non-affected areas in recent years. Identification of new …

Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the
three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses …

The present review addresses basic aspects of the biology of the pathogenic protozoa
Trypanosoma cruzi and some comparative information of Trypanosoma brucei. Like …

Leucine, isoleucine, and valine, collectively termed Branched Chain Amino Acids (BCAA),
are hydrophobic amino acids (AAs) and are essential for most eukaryotes since in these …

Glycosomes are peroxisome-related organelles that have been identified in kinetoplastids
and diplonemids. The hallmark of glycosomes is their harboring of the majority of the …

Cholesterol biosynthesis is a multi-step process involving several subcellular compartments,
including peroxisomes. Cells adjust their sterol content by both transcriptional and post …

The cellular membranes of Trypanosoma cruzi, like all eukaryotes, contain varying amounts
of phospholipids, sphingolipids, neutral lipids and sterols. A multitude of pathways exist for …

Kinetoplastea and Diplonemea possess peroxisome‐related organelles that, uniquely,
contain most of the enzymes of the glycolytic pathway and are hence called glycosomes …

Trypanosoma cruzi, the parasite causing Chagas disease, is a digenetic flagellated protist
that infects mammals (including humans) and reduviid insect vectors. Therefore, T. cruzi …