Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Triggering of the T cell receptor (TCR) integrates both binding kinetics and mechanical
forces. To understand the contribution of the T cell cytoskeleton to these forces, we triggered …

Although myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has a specific and
distinctive profile of clinical features, the disease remains an enigma because causal …

In response to various stressors, cardiac chambers undergo structural remodeling. Long-
term exposure of the right ventricle (RV) to pressure or volume overload leads to its …

Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling.
CFS symptoms can be provoked by increased physical or cognitive activity, and by …

Background Pediatric tuina is an effective alternative therapy for managing spleen
deficiency diarrhea. The application of spleen-meridian and large-intestine-meridian points …

Mast cell degranulation is the typical anaphylaxis process of mast cells associated with the
release of cytokines, eicosanoids and their secretory granules, which play very important …

Bioactive immunomodulatory biomaterials have shown promise for influencing the immune
response to promote tissue repair and regeneration. Macrophages and T cells have been …

Delivering molecules onto the plasma membrane of single cells is still a challenging task in
profiling cell signaling pathways with single cell resolution. We demonstrated that a large …

In spite of decades of research, the pathobiology of Myalgic Encephalomyelitis/Chronic
Fatigue Syndrome (ME/CFS) is still poorly understood. Several pathomechanisms have …