Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …
Age-related macular degeneration and neurodegenerative disorders: Shared pathways in complex interactions
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
elderly, and neurodegenerative disorders such as Alzheimer disease and Parkinson …
elderly, and neurodegenerative disorders such as Alzheimer disease and Parkinson …
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway
J Xu, YL Ao, C Huang, X Song, G Zhang, W Cui… - npj Parkinson's …, 2022 - nature.com
The abnormal accumulation of α-synuclein (α-syn) is a crucial factor for the onset and
pathogenesis of Parkinson's disease (PD), and the autophagy-lysosome pathway (ALP) …
pathogenesis of Parkinson's disease (PD), and the autophagy-lysosome pathway (ALP) …
The unified multiple system atrophy rating scale: status, critique, and recommendations
The Unified Multiple System Atrophy Rating Scale (UMSARS) was developed almost two
decades ago as a clinical rating scale to capture multiple aspects of the disease. 1, 2 It is …
decades ago as a clinical rating scale to capture multiple aspects of the disease. 1, 2 It is …
Multiple system atrophy
Multiple system atrophy (MSA) is a rare neurodegenerative disease that is characterized by
neuronal loss and gliosis in multiple areas of the central nervous system including …
neuronal loss and gliosis in multiple areas of the central nervous system including …
Autophagy and autophagic cell death in sepsis: friend or foe?
In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and
survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions …
survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions …
Targeting ageing with rapamycin and its derivatives in humans: a systematic review
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the
ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the …
ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the …
Pathogenic aspects and therapeutic avenues of autophagy in Parkinson's disease
The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …
not have any curative treatment turn out to be essential issues in the following years, where …
[HTML][HTML] FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism
C Cheng, M Deng, C Cheng, H Wu, Y Wang… - Journal of Orthopaedic …, 2024 - Elsevier
Background As the population aging progresses, age-related osteoporosis has become one
of the most common and severe chronic degenerative diseases. Due to insufficient …
of the most common and severe chronic degenerative diseases. Due to insufficient …
The role of autophagy-lysosomal pathway in motor neuron diseases
B Tedesco, V Ferrari, M Cozzi… - Biochemical Society …, 2022 - portlandpress.com
Motor neuron diseases (MNDs) include a broad group of diseases in which
neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the …
neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the …