Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Osteoarthritis (OA) is a disabling condition that affects billions of people worldwide and
places a considerable burden on patients and on society owing to its prevalence and …

Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …

Sirt6 has been implicated as a key regulator in aging-related diseases, including
osteoarthritis. However, its functional role and molecular mechanism in chondrocyte …

Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor
vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical …

Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

OBJECTIVE: Age-related changes in multiple components of the musculoskeletal system
may contribute to the well established link between aging and osteoarthritis (OA). This …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Mitochondria are important regulators of cellular function and survival that may have a key
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …