Proteomics technologies for cancer liquid biopsies
Alterations in DNAs could not reveal what happened in proteins. The accumulated
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …
alterations of DNAs would change the manifestation of proteins. Therefore, as is the case in …
Targeting AKT for cancer therapy
Introduction: Targeted therapies in cancer aim to inhibit specific molecular targets
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
responsible for enhanced tumor growth. AKT/PKB (protein kinase B) is a serine threonine …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
Recent advances in PI3K/PKB/mTOR inhibitors as new anticancer agents
The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …
now well known. During the onset and development of different forms of cancer it becomes …
[HTML][HTML] Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology
Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous
threats to mount a protective proinflammatory innate immune response. PRRs may be …
threats to mount a protective proinflammatory innate immune response. PRRs may be …
Circulating miR-320a acts as a tumor suppressor and prognostic factor in non-small cell lung cancer
Dysregulated expression profiles of microRNAs (miRNAs) have been observed in several
types of cancer, including non-small cell lung cancer (NSCLC); however, the diagnostic and …
types of cancer, including non-small cell lung cancer (NSCLC); however, the diagnostic and …
AKT kinases as therapeutic targets
AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a
range of normal cellular physiologies that also underlie several pathological conditions …
range of normal cellular physiologies that also underlie several pathological conditions …
Research progress in protein microarrays: Focussing on cancer research
G Chen, L Yang, G Liu, Y Zhu, F Yang… - PROTEOMICS …, 2023 - Wiley Online Library
Although several effective treatment modalities have been developed for cancers, the
morbidity and mortality associated with cancer continues to increase every year. As one of …
morbidity and mortality associated with cancer continues to increase every year. As one of …
AKT and the Hallmarks of Cancer
Nearly a quarter century ago, Hanahan and Weinberg conceived six unifying principles
explaining how normal cells transform into malignant tumors. Their provisional set of …
explaining how normal cells transform into malignant tumors. Their provisional set of …
Melatonin abrogates the anti-developmental effect of the AKT inhibitor SH6 in bovine oocytes and embryos
Melatonin, a nighttime-secreted antioxidant hormone produced by the pineal gland, and
AKT, a serine/threonine-specific protein kinase, have been identified as regulators for …
AKT, a serine/threonine-specific protein kinase, have been identified as regulators for …