Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia
B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …
Vascular dysfunction in the pathogenesis of Alzheimer's disease—A review of endothelium-mediated mechanisms and ensuing vicious circles
Late-onset dementia is a major health concern in the ageing population. Alzheimer's
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …
disease (AD) accounts for the largest proportion (65–70%) of dementia cases in the older …
Blood–brain barrier dysfunction as a cause and consequence of Alzheimer's disease
The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …
system (CNS) homeostasis. Dysfunction of the BBB occurs in a number of CNS diseases …
Neuroprotective effect of quercetin nanoparticles: A possible prophylactic and therapeutic role in alzheimer's disease
Background Alzheimer's disease (AD) is the most common cause of dementia in elderly.
Quercetin is a well-known flavonoid with low bioavailability. Recently, quercetin …
Quercetin is a well-known flavonoid with low bioavailability. Recently, quercetin …
Surface charge, glycocalyx, and blood-brain barrier function
The negative surface charge of brain microvessel endothelial cells is derived from the
special composition of their membrane lipids and the thick endothelial surface glycocalyx …
special composition of their membrane lipids and the thick endothelial surface glycocalyx …
Suppression of Oligomer Formation and Formation of Non‐Toxic Fibrils upon Addition of Mirror‐Image Aβ42 to the Natural l‐Enantiomer
Racemates often have lower solubility than enantiopure compounds, and the mixing of
enantiomers can enhance the aggregation propensity of peptides. Amyloid beta (Aβ) 42 is …
enantiomers can enhance the aggregation propensity of peptides. Amyloid beta (Aβ) 42 is …
Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses
EH Schuchman, Y Ge, A Lai, Y Borisov, M Faillace… - PloS one, 2013 - journals.plos.org
Background Pentosan polysulfate (PPS) is an FDA-approved, oral medication with anti-
inflammatory and pro-chondrogenic properties. We have previously shown that animal …
inflammatory and pro-chondrogenic properties. We have previously shown that animal …
[HTML][HTML] Ginseng polysaccharides: A potential neuroprotective agent
N Wang, X Wang, M He, W Zheng, D Qi… - Journal of Ginseng …, 2021 - Elsevier
The treatments of nervous system diseases (NSDs) have long been difficult issues for
researchers because of their complexity of pathogenesis. With the advent of aging society …
researchers because of their complexity of pathogenesis. With the advent of aging society …
Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice
Background High-dose radiation-induced blood-brain barrier breakdown contributes to
acute radiation toxicity syndrome and delayed brain injury, but there are few data on the …
acute radiation toxicity syndrome and delayed brain injury, but there are few data on the …
[HTML][HTML] Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity
Y Li, S Zhou, J Li, Y Sun, H Hasimu, R Liu… - … Pharmaceutica Sinica B, 2015 - Elsevier
Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain
barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the …
barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the …