The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Bacterial pathogens have evolved a wide range of strategies to colonize and invade human
organs, despite the presence of multiple host defense mechanisms. In this review, we will …

The central nervous system (CNS) and its meningeal coverings accommodate a diverse
myeloid compartment that includes parenchymal microglia and perivascular macrophages …

Since the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs)
in order to model the blood–brain barrier (BBB) in vitro, the need for a human BBB model …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

The brain is well protected against microbial invasion by cellular barriers, such as the blood-
brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). In addition, cells …

The blood–brain barrier, which is one of the tightest barriers in the body, protects the brain
from insults, such as infections. Indeed, only a few of the numerous blood-borne bacteria …

SUMMARY Type IV pili (T4P) are multifunctional protein fibers produced on the surfaces of a
wide variety of bacteria and archaea. The major subunit of T4P is the type IV pilin, and …

The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …