5‑Fluorouracil and capecitabine therapies for the treatment of colorectal cancer

SM Alzahrani, HA Al Doghaither… - Oncology …, 2023 - spandidos-publications.com
Although 5-fluorouracil (5-FU)-based chemotherapy is the major treatment for colorectal
cancer, it has disadvantages such as systemic toxicity, lack of effectiveness and selectivity …

Multifunctional microrobot with real-time visualization and magnetic resonance imaging for chemoembolization therapy of liver cancer

G Go, A Yoo, KT Nguyen, M Nan, BA Darmawan… - Science …, 2022 - science.org
Microrobots that can be precisely guided to target lesions have been studied for in vivo
medical applications. However, existing microrobots have challenges in vivo such as …

Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems

B Tian, Y Liu, J Liu - Carbohydrate polymers, 2020 - Elsevier
Cancer has been a threat to human health, so its treatment is a huge challenge to the
present medical field. One of commonly used methods is the controlled release of anticancer …

Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection …

H Hao, Y Zhang, X Hu, W Guo, C Yang… - European Journal of …, 2023 - Elsevier
Gallic acid (GA) is a naturally occurring polyphenolic compound exhibiting anti-tumor
activity. To clarify the capability of GA in optimizing the in vitro/in vivo properties of the first …

[HTML][HTML] Alginate/geopolymer hybrid beads as an innovative adsorbent applied to the removal of 5-fluorouracil from contaminated environmental water

AB Amor, M Arenas, J Martín, A Ouakouak, JL Santos… - Chemosphere, 2023 - Elsevier
Water contaminated by cytostatic drugs has many negative impacts on the ecosystems. In
this work, cross-linked adsorbent beads based on alginate and a geopolymer (prepared …

Folic acid functionalized carbon nanotubes as pH controlled carriers of fluorouracil: Molecular dynamics simulations

M Yahyavi, F Badalkhani-Khamseh… - Journal of Molecular …, 2023 - Elsevier
This study deals with molecular dynamics simulations of the folic acid (FA) functionalized
carbon nanotube (CNT) as a pH-responsive carrier of fluorouracil (5-FU) drug. We chose FA …

Bovine Serum Albumin as a Platform for Designing Biologically Active Nanocarriers—Experimental and Computational Studies

O Adamczyk, M Szota, K Rakowski… - International Journal of …, 2023 - mdpi.com
Due to the specificity of their structure, protein systems are adapted to carry various ligands.
The structure of many proteins potentially allows for two types of immobilization of a …

The effect of niosome preparation methods in encapsulating 5-fluorouracil and real time cell assay against HCT-116 colon cancer cell line

OL Ugorji, ONC Umeh, CO Agubata, D Adah, NC Obitte… - Heliyon, 2022 - cell.com
The formulation of niosomes is influenced by a number of variables, and these variables
may eventually affect the formulation's outcome. One of the elements that can influence the …

Exploring pH dependent delivery of 5-fluorouracil from functionalized multi-walled carbon nanotubes

A Solhjoo, Z Sobhani, A Sufali, Z Rezaei… - Colloids and Surfaces B …, 2021 - Elsevier
Multi-walled carbon nanotubes (MWCNTs) can be applied for pH-sensitive delivery of
anticancer drugs. Due to the importance of 5-fluorouracil (5-FU) in different tumor therapy …

pH-sensitive polyacrylic acid-gated mesoporous silica nanocarrier incorporated with calcium ions for controlled drug release

J Kong, SS Park, CS Ha - Materials, 2022 - mdpi.com
In this work, polyacrylic acid-functionalized MCM-41 was synthesized, which was made to
interact with calcium ions, in order to realize enhanced pH-responsive nanocarriers for …