Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Monocytes and macrophages in abdominal aortic aneurysm

J Raffort, F Lareyre, M Clément… - Nature Reviews …, 2017 - nature.com
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high
morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

T Hadi, L Boytard, M Silvestro, D Alebrahim… - Nature …, 2018 - nature.com
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

Abdominal aortic aneurysm: novel mechanisms and therapies

FM Davis, DL Rateri, A Daugherty - Current opinion in cardiology, 2015 - journals.lww.com
Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion in
Cardiology Abdominal aortic aneurysm: novel mechanisms and therapies : Current Opinion …

Cytokines in abdominal aortic aneurysm: master regulators with clinical application

OA Puchenkova, VO Soldatov, AE Belykh… - Biomarker …, 2022 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disorder with a mostly
asymptomatic course where the abdominal aorta is weakened and bulged. Cytokines play …

The role of CXC chemokines in cardiovascular diseases

X Lu, Z Wang, D Ye, Y Feng, M Liu, Y Xu… - Frontiers in …, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a class of diseases with high disability and mortality rates.
In the elderly population, the incidence of cardiovascular disease is increasing annually …

Modulation of immune‐inflammatory responses in abdominal aortic aneurysm: Emerging molecular targets

H Li, S Bai, Q Ao, X Wang, X Tian, X Li… - Journal of …, 2018 - Wiley Online Library
Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice

Z Wang, J Guo, X Han, M Xue, W Wang, L Mi, Y Sheng… - Cell & bioscience, 2019 - Springer
Background The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA)
has been reported. However, the related mechanism is still poor understood. In this study …

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level

H Wu, C **e, R Wang, J Cheng, Q Xu… - Frontiers in …, 2023 - frontiersin.org
Introduction: Aortic aneurysm is a life-threatening disease resulted from progressive
dilatation of the aorta, which can be subdivided into thoracic and abdominal aortic …