The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Cyclin D1 is an important regulator of cell cycle progression and can function as a
transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the …

Effective methods are needed to identify and isolate those genes that are differentially
expressed in various cells or under altered conditions. This report describes a method to …

Phenotypic cell-to-cell variability within clonal populations may be a manifestation of 'gene
expression noise',,,,,, or it may reflect stable phenotypic variants. Such 'non-genetic cell …

The cell cycle is the series of events that take place in a cell that drives it to divide and
produce two new daughter cells. Through more than 100 years of efforts by scientists, we …

A New Avenue of Research Beyond Traditional Studies of Vitamin E In the current literature,
more than 95% of all studies of vitamin E are directed toward the specific exploration of the …

HIV-1 particle production occurs in a series of steps promoted by the viral Gag protein.
Although it is well established that assembly and release take place at the plasma …

Abstract The statin drugs ('statins') potently inhibit hydroxymethylglutaryl-coenzyme A (HMG-
CoA) reductase by competitively blocking the active site of the enzyme. Statins decrease de …

Hydroxy-3-methylgutaryl CoA reductase inhibitors, commonly referred to as the statins, have
proven therapeutic and preventative effects in cardiovascular diseases. Recently, there are …

The statin family of drugs target HMG-CoA reductase, the rate-limiting enzyme of the
mevalonate pathway, and have been used successfully in the treatment of …