Robust and efficient processes are needed to establish scientific confidence in new
approach methodologies (NAMs) if they are to be considered for regulatory applications …

Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Animal testing is used in pharmaceutical and industrial research to predict human toxicity,
and yet analysis suggests that animal models are poor predictors of drug safety in humans …

This Guidance describes how to perform hazard identification for endocrine‐disrupting
properties by following the scientific criteria which are outlined in Commission Delegated …

In 2016, the Frank R. Lautenberg Chemical Safety for the 21st Century Act became the first
US legislation to advance chemical safety evaluations by utilizing novel testing approaches …

Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …

Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Surface waters can contain a diverse range of organic pollutants, including pesticides,
pharmaceuticals and industrial compounds. While bioassays have been used for water …

Background The traditional approaches to toxicity testing have posed multiple challenges for
evaluating the safety of industrial and environmental chemicals, pesticides, food additives …

We demonstrate a computational network model that integrates 18 in vitro, high-throughput
screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin …