Microbiological applications of high-resolution melting analysis
High-resolution melting (HRM) analysis uses real-time PCR instrumentation to interrogate
DNA sequence variation and is a low-cost, single-step, closed-tube method. Here we …
DNA sequence variation and is a low-cost, single-step, closed-tube method. Here we …
[HTML][HTML] Malaria diagnostics in clinical trials
Malaria diagnostics are widely used in epidemiologic studies to investigate natural history of
disease and in drug and vaccine clinical trials to exclude participants or evaluate efficacy …
disease and in drug and vaccine clinical trials to exclude participants or evaluate efficacy …
Modeling malaria genomics reveals transmission decline and rebound in Senegal
To study the effects of malaria-control interventions on parasite population genomics, we
examined a set of 1,007 samples of the malaria parasite Plasmodium falciparum collected in …
examined a set of 1,007 samples of the malaria parasite Plasmodium falciparum collected in …
A Biotinylated cpFIT-PNA Platform for the Facile Detection of Drug Resistance to Artemisinin in Plasmodium falciparum
The evolution of drug resistance to many antimalarial drugs in the lethal strain of malaria
(Plasmodium falciparum) has been a great concern over the past 50 years. Among these …
(Plasmodium falciparum) has been a great concern over the past 50 years. Among these …
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
The emergence of drug resistance is a major limitation of current antimalarials. The
discovery of new druggable targets and pathways including those that are critical for multiple …
discovery of new druggable targets and pathways including those that are critical for multiple …
High throughput resistance profiling of Plasmodium falciparum infections based on custom dual indexing and Illumina next generation sequencing-technology
S Nag, MD Dalgaard, PE Kofoed, J Ursing, M Crespo… - Scientific reports, 2017 - nature.com
Genetic polymorphisms in P. falciparum can be used to indicate the parasite's susceptibility
to antimalarial drugs as well as its geographical origin. Both of these factors are key to …
to antimalarial drugs as well as its geographical origin. Both of these factors are key to …
Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections
Plasmodium vivax, one of the five species of Plasmodium parasites that cause human
malaria, is responsible for 25–40% of malaria cases worldwide. Malaria global elimination …
malaria, is responsible for 25–40% of malaria cases worldwide. Malaria global elimination …
Clonal Outbreak of Plasmodium falciparum Infection in Eastern Panama
Identifying the source of resurgent parasites is paramount to a strategic, successful
intervention for malaria elimination. Although the malaria incidence in Panama is low, a …
intervention for malaria elimination. Although the malaria incidence in Panama is low, a …
Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa
AN Wotodjo, MA Oboh, S Doucoure, N Diagne… - Malaria journal, 2023 - Springer
Background Thanks to the scale up of malaria control interventions, the malaria burden in
Senegal has decreased substantially to the point that the National Malaria Control …
Senegal has decreased substantially to the point that the National Malaria Control …
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
REK Mandt, MJ Lafuente-Monasterio… - Science translational …, 2019 - science.org
Resistance has developed in Plasmodium malaria parasites to every antimalarial drug in
clinical use, prompting the need to characterize the pathways mediating resistance. Here …
clinical use, prompting the need to characterize the pathways mediating resistance. Here …