Various types of biological materials have been developed and applied for tissue
regeneration and wound repair. Among them, hydrogel fibers obtained by combining …

In recent years, dynamic,'click'hydrogels have been applied in numerous biomedical
applications. Owing to the mild, cytocompatible, and highly specific reaction kinetics, a …

Peptides capable of forming homotetrameric coiled-coil bundles are utilized as monomeric
building blocks (“bundlemers”) to synthesize protein-like hybrid polymers consisting of …

Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group
via the first example of a Ag-mediated Liebeskind–Srogl cross-coupling. The attachment of …

Liver injury, both acute and chronic, poses a significant threat to human health, resulting in
high morbidity and mortality rates. The current challenges in the treatment of liver injury are …

Repeated mechanical and chemical insults cause an irreversible alteration of extracellular
matrix (ECM) composition and properties, giving rise to vocal fold scarring that is refractory …

The advent of the click chemistry paradigm has profoundly transformed the design of
functional polymeric materials. Among the various reactions in the click chemistry toolkit, the …

Described herein is a protocol for producing a synthetic extracellular matrix that can be
modified in situ during three-dimensional cell culture. The hydrogel platform is established …

Crosslinked, degradable, and cell-adhesive hydrogel microfibers were synthesized via
interfacial polymerization employing tetrazine ligation, an exceptionally fast bioorthogonal …

Chemical modification of engineered microenvironments surrounding living cells represents
a means for directing cellular behaviors through cell–matrix interactions. Presented here is a …