1, 2, 3‐Triazole hybrids as anticancer agents: A review

MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …

Design, synthesis, molecular modeling, anticancer studies, and density functional theory calculations of 4-(1, 2, 4-triazol-3-ylsulfanylmethyl)-1, 2, 3-triazole derivatives

A Al Sheikh Ali, D Khan, A Naqvi, FF Al-Blewi… - ACS …, 2020 - ACS Publications
New conjugates of substituted 1, 2, 3-triazoles linked to 1, 2, 4-triazoles were synthesized
starting from the appropriate S-propargylated 1, 2, 4-triazoles 7 and 8. Ligation of 1, 2, 4 …

SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation

G He, Y Zhang, Y Feng, T Chen, M Liu… - Journal of Cellular …, 2024 - Wiley Online Library
SBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis
of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in …

Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition

MS Nafie, SM Kishk, S Mahgoub… - Chemical Biology & …, 2022 - Wiley Online Library
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …

Recent progress on apoptotic activity of triazoles

P Çıkla-Süzgün, ŞG Küçükgüzel - Current drug targets, 2021 - ingentaconnect.com
Apoptosis is often called programmed cell death and is defined as a self-directed cell
destruction process. It is different from necrosis due to the activation of caspases during this …

Synthesis and antimalarial and anticancer evaluation of 7‐chlorquinoline‐4‐thiazoleacetic derivatives containing aryl hydrazide moieties

H Ramírez, E Fernandez, J Rodrigues… - Archiv der …, 2021 - Wiley Online Library
Twelve 7‐chloroquinoline derivatives were designed and synthesized using the principle of
molecular hybridization through the coupling of 2‐[2‐(7‐chloroquinolin‐4‐ylthio)‐4 …

Synthesis, characterization and cytotoxic activity evaluation of 4-(1, 2, 3-triazol-1-yl) salicylic acid derivatives

ZG Ríos-Malváez, MA Cano-Herrera… - Journal of Molecular …, 2021 - Elsevier
Abstract A novel series of 4-(1, 2, 3-triazol-1-yl) salicylic acid derivatives was synthesized
from 4-azidosalicylic acid and diverse alkynes using copper catalyzed azide-alkyne …

Hybridized 4‐Trifluoromethyl‐(1, 2, 3‐triazol‐1‐yl) quinoline System: Synthesis, Photophysics, Selective DNA/HSA Bio‐interactions and Molecular Docking

YG Kappenberg, FS Stefanello, N Zanatta… - …, 2022 - Wiley Online Library
The synthesis, structural analysis, and evaluation of the photophysical properties of twelve
novel 2‐aryl (heteroaryl)‐6‐(4‐alkyl (aryl)‐1H‐1, 2, 3‐triazol‐1‐yl)‐4‐(trifluoromethyl) …

New 3‐(1H‐benzo[d]imidazol‐2‐yl)quinolin‐2(1H)‐one‐based triazole derivatives: Design, synthesis, and biological evaluation as antiproliferative and apoptosis …

NB Gaikwad, S Bansode, S Biradar, M Ban… - Archiv der …, 2021 - Wiley Online Library
Abstract A series of 1, 2, 3‐triazole derivatives based on the quinoline–benzimidazole hybrid
scaffold was designed, synthesized, and screened against a panel of NCI‐60 humanoid …

Synthesis of [1,2,3]Triazolo[1,5‐a]quinoline‐3‐carboxamides Promoted by Organocatalyst and Base

GP Da Costa, GB Blödorn, T Barcellos… - European Journal of …, 2023 - Wiley Online Library
We described here a simple and metal‐free protocol to synthesize [1, 2, 3] triazolo [1, 5‐a]
quinoline 3‐carboxamides through a two‐step synthetic strategy, in which the first step uses …