[HTML][HTML] The impact of Di-(2-ethylhexyl) Phthalate and Mono (2-ethylhexyl) Phthalate in placental development, function, and pathophysiology

LD Martínez-Razo, A Martínez-Ibarra… - Environment …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the
environment as is extensively used in the plastic industry. DEHP is considered an endocrine …

Phthalate exposure and risk of diabetes mellitus: Implications from a systematic review and meta-analysis

H Zhang, Y Ben, Y Han, Y Zhang, Y Li, X Chen - Environmental Research, 2022 - Elsevier
Background Epidemiologic studies indicated that phthalate exposure might be associated
with diabetes mellitus (DM). However, discrepancies existed. The link between phthalate …

[HTML][HTML] Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic …

A Schaffert, I Karkossa, E Ueberham… - Environment …, 2022 - Elsevier
The obesity pandemic is presumed to be accelerated by endocrine disruptors such as
phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the …

[HTML][HTML] Concentrations and endocrine disruptive potential of phthalates in marine mammals from the Norwegian Arctic

H Routti, M Harju, K Lühmann, J Aars, A Ask… - Environment …, 2021 - Elsevier
This study investigated concentrations of phthalates (diesters of phthalic acids) in
blubber/adipose tissue of blue whales (Balaenoptera musculus), fin whales (Balaenoptera …

[HTML][HTML] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation

A Schaffert, L Krieg, J Weiner, R Schlichting… - Environment …, 2021 - Elsevier
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was
reported to cause adverse effects, including disruption of adipocyte differentiation …

[HTML][HTML] Structural basis of the activation of PPARγ by the plasticizer metabolites MEHP and MINCH

A Useini, F Engelberger, G Künze, N Sträter - Environment International, 2023 - Elsevier
Abstract Di-2-ethylhexyl phthalate (DEHP) and its substitute 1, 2-cyclohexane dicarboxylic
acid diisononyl ester (DINCH) are widely used as plasticizers but may have adverse health …

The emerging plasticizer alternative DINCH and its metabolite MINCH induce oxidative stress and enhance inflammatory responses in human THP-1 macrophages

A Schaffert, J Arnold, I Karkossa, M Blüher… - Cells, 2021 - mdpi.com
The use of the plasticizer bis (2-ethylhexyl) phthalate (DEHP) and other plasticizers in the
manufacture of plastic products has been restricted due to adverse health outcomes such as …

Phthalate monoesters act through peroxisome proliferator-activated receptors in the mouse ovary

DD Meling, M Kathy, AS Arango, A Gonsioroski… - Reproductive …, 2022 - Elsevier
Widespread use of phthalates as solvents and plasticizers leads to everyday human
exposure. The mechanisms by which phthalate metabolites act as ovarian toxicants are not …

Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea

Z **e, X Zhang, Y **e, J Wu, Y Wu - Journal of Hazardous Materials, 2023 - Elsevier
Phthalate esters (PAEs) are ubiquitous environmental contaminants, arising growing public
concern. Nevertheless, information on the exposure and risks of PAEs in wildlife remains …

Association of parental preconception exposure to phthalates and phthalate substitutes with preterm birth

Y Zhang, V Mustieles, J Yland, JM Braun… - JAMA network …, 2020 - jamanetwork.com
Importance Although phthalate exposure during pregnancy has been associated with
preterm birth, the association of preconception exposure in either parent with preterm birth …