Stress related disorders such as depression and anxiety are leading sources of disability
worldwide, and current treatment methods such as conventional antidepressant medications …

Despite decades of research aimed at identifying the causes of postpartum depression
(PPD), PPD remains common, and the causes are poorly understood. Many have attributed …

Unipolar depressive disorder in adolescence is common worldwide but often unrecognised.
The incidence, notably in girls, rises sharply after puberty and, by the end of adolescence …

Dehydroepiandrosterone (DHEA) and cortisol are the most abundant hormones of the
human fetal and adult adrenals released as end products of a tightly coordinated endocrine …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

Corticotropin-releasing hormone (CRH) plays a central role in the regulation of the
hypothalamic-pituitary-adrenal (HPA)-axis, ie, the final common pathway in the stress …

The awakening cortisol response (ACR) is a discrete and distinctive part of the cortisol
circadian cycle. In healthy adults salivary free cortisol concentrations increase by between …

The steroid cortisol is an extensively studied and important variable in developmental and
other behavioral studies. Cortisol has been assayed by various methods using a range of …

Inconsistencies exist in literature examining hypothalamic–pituitary–adrenal (HPA) axis
activity in children and adults who have experienced childhood abuse. Hence, the extent …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …