The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

The pathology of type 2 diabetes is complex, with multiple stages culminating in a functional
β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Despite significant research, mechanisms underlying the failure of islet beta cells that result
in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a …

The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver
disease, is dramatically increasing. Both genetic and environmental factors are well-known …

The Wnt signaling pathway is critically important not only for stem cell amplification,
differentiation, and migration, but also is important for organogenesis and the development …

Diabetes occurs when β-cells no longer function properly or have been destroyed.
Pancreatic β-cell death by apoptosis contributes significantly in both autoimmune type 1 …

Environmentally induced or epigenetic-related beta-cell dysfunction and insulin resistance
play a critical role in the progression to diabetes. We developed a mathematical modeling …

We previously cataloged putative autocrine/paracrine signaling loops in pancreatic islets,
including factors best known for their roles in axon guidance. Emerging evidence points to …

Objective The role and mechanisms of insulin receptor internalization remain incompletely
understood. Previous trafficking studies of insulin receptors involved fluorescent protein …