Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent ailment worldwide.
Moreover, de novo lipogenesis (DNL) is considered a critical factor in the development of …

Exposure of the airways epithelium to environmental insults, including cigarette smoke,
results in increased oxidative stress due to unbalance between oxidants and antioxidants in …

Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial
quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays …

Cancer cells, particularly in solid tumors, are surrounded by non-neoplastic elements,
including endothelial and stromal cells, as well as cells of immune origin, which can support …

In recent years, researchers have begun to realize the importance of the role of non-coding
RNAs in the treatment of cancer and cardiovascular and neurological diseases. LncRNAs …

Sirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell
metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the …