Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Silent information regulator (SIRT) has distinctive enzymatic activities and physiological
functions to control cell-cycle progression, gene expression, and DNA stability by targeting …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent ailment worldwide.
Moreover, de novo lipogenesis (DNL) is considered a critical factor in the development of …

The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial
quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays …

Sirtuins are pivotal in orchestrating numerous cellular pathways, critically influencing cell
metabolism, DNA repair, aging processes, and oxidative stress. In recent years, the …

Exposure of the airways epithelium to environmental insults, including cigarette smoke,
results in increased oxidative stress due to unbalance between oxidants and antioxidants in …

Neurodegenerative diseases (NDDs) are identified by the progressive deterioration of
neurons and a subsequent decline in cognitive function, creating an enormous burden on …