Tailoring biomaterials for biomimetic organs-on-chips
Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
continuously perfused chambers penetrating to cells. By mimicking the biological features of …
Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors
F Xu, H **, L Liu, Y Yang, J Cen, Y Wu… - Microsystems & …, 2024 - nature.com
Abstract Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for
the development of engineered cardiac tissue, facilitating high-throughput testing in drug …
the development of engineered cardiac tissue, facilitating high-throughput testing in drug …
Microfluidics: a concise review of the history, principles, design, applications, and future outlook
MI Hajam, MM Khan - Biomaterials Science, 2024 - pubs.rsc.org
Microfluidic technologies have garnered significant attention due to their ability to rapidly
process samples and precisely manipulate fluids in assays, making them an attractive …
process samples and precisely manipulate fluids in assays, making them an attractive …
In situ biosensing technologies for an organ-on-a-chip
The in vitro simulation of organs resolves the accuracy, ethical, and cost challenges
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
accompanying in vivo experiments. Organoids and organs-on-chips have been developed …
Current strategies of mechanical stimulation for maturation of cardiac microtissues
M Carlos-Oliveira, F Lozano-Juan, P Occhetta… - Biophysical …, 2021 - Springer
The most advanced in vitro cardiac models are today based on the use of induced
pluripotent stem cells (iPSCs); however, the maturation of cardiomyocytes (CMs) has not yet …
pluripotent stem cells (iPSCs); however, the maturation of cardiomyocytes (CMs) has not yet …
[HTML][HTML] Liver–Heart on chip models for drug safety
Current pre-clinical models to evaluate drug safety during the drug development process
(DDP) mainly rely on traditional two-dimensional cell cultures, considered too simplistic and …
(DDP) mainly rely on traditional two-dimensional cell cultures, considered too simplistic and …
In vitro mechanical stimulation to reproduce the pathological Hallmarks of human cardiac fibrosis on a beating chip and predict the efficacy of drugs and advanced …
Cardiac fibrosis is one of the main causes of heart failure, significantly contributing to
mortality. The discovery and development of effective therapies able to heal fibrotic …
mortality. The discovery and development of effective therapies able to heal fibrotic …
Microphysiological constructs and systems: biofabrication tactics, biomimetic evaluation approaches, and biomedical applications
In recent decades, microphysiological constructs and systems (MPCs and MPSs) have
undergone significant development, ranging from self‐organized organoids to high …
undergone significant development, ranging from self‐organized organoids to high …
Building blocks of microphysiological system to model physiology and pathophysiology of human heart
H Vuorenpää, M Björninen, H Välimäki, A Ahola… - Frontiers in …, 2023 - frontiersin.org
Microphysiological systems (MPS) are drawing increasing interest from academia and from
biomedical industry due to their improved capability to capture human physiology. MPS offer …
biomedical industry due to their improved capability to capture human physiology. MPS offer …
[HTML][HTML] Continuous contractile force and electrical signal recordings of 3D cardiac tissue utilizing conductive hydrogel pillars on a chip
Heart-on-chip emerged as a potential tool for cardiac tissue engineering, recapitulating key
physiological cues in cardiac pathophysiology. Controlled electrical stimulation and the …
physiological cues in cardiac pathophysiology. Controlled electrical stimulation and the …