P4-ATPases as phospholipid flippases—structure, function, and enigmas
JP Andersen, AL Vestergaard, SA Mikkelsen… - Frontiers in …, 2016 - frontiersin.org
P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
across cell membranes. This generates and maintains membrane lipid asymmetry, a …
Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flip**
TG Pomorski, AK Menon - Progress in lipid research, 2016 - Elsevier
Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
M Hiraizumi, K Yamashita, T Nishizawa, O Nureki - Science, 2019 - science.org
In eukaryotic membranes, type IV P-type adenosine triphosphatases (P4-ATPases) mediate
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …
the translocation of phospholipids from the outer to the inner leaflet and maintain lipid …
Structure and autoregulation of a P4-ATPase lipid flippase
Abstract Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …
transport of phospholipids from exoplasmic or luminal leaflets to cytosolic leaflets of …
Transport cycle of plasma membrane flippase ATP11C by cryo-EM
H Nakanishi, T Nishizawa, K Segawa, O Nureki… - Cell reports, 2020 - cell.com
ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution
of phosphatidylserine accumulated in the inner leaflet. Caspase-dependent inactivation of …
of phosphatidylserine accumulated in the inner leaflet. Caspase-dependent inactivation of …
Transport through recycling endosomes requires EHD 1 recruitment by a phosphatidylserine translocase
P4‐ATP ases translocate aminophospholipids, such as phosphatidylserine (PS), to the
cytosolic leaflet of membranes. PS is highly enriched in recycling endosomes (RE s) and is …
cytosolic leaflet of membranes. PS is highly enriched in recycling endosomes (RE s) and is …
Fast-forward on P-type ATPases: recent advances on structure and function
C Stock, T Heger, S Basse Hansen… - Biochemical Society …, 2023 - portlandpress.com
P-type ATPase are present in nearly all organisms. They maintain electrochemical gradients
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …
P4-ATPases: lipid flippases in cell membranes
Cellular membranes, notably eukaryotic plasma membranes, are equipped with special
proteins that actively translocate lipids from one leaflet to the other and thereby help …
proteins that actively translocate lipids from one leaflet to the other and thereby help …