The largest epidemic ever recorded for chikungunya, a disease caused by infection with the
chikungunya virus (CHIKV), began in Africa in 2004 and spread to> 100 countries on four …

Alphaviruses are arthropod-transmitted RNA viruses that cause epidemics of human
infection and disease on a global scale. These viruses are classified as either arthritogenic …

SARS-CoV-2 is an enveloped virus responsible for the COVID-19 pandemic. Despite recent
advances in the structural elucidation of SARS-CoV-2 proteins, the detailed architecture of …

DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …

Background Chikungunya virus (CHIKV) is an Aedes mosquito-borne virus that has caused
large epidemics linked to acute, chronic, and severe clinical outcomes. Currently, Brazil has …

Chikungunya virus (CHIKV) is a representative alphavirus causing debilitating arthritogenic
disease in humans. Alphavirus particles assemble into two icosahedral layers: the …

Alphaviruses are emerging, mosquito-transmitted pathogens that cause musculoskeletal
and neurological disease in humans. Although neutralizing antibodies that inhibit individual …

We review the emerging method of super-resolved cryogenic correlative light and electron
microscopy (srCryoCLEM). Super-resolution (SR) fluorescence microscopy and cryogenic …

MXRA8 is a receptor for chikungunya (CHIKV) and other arthritogenic alphaviruses with
mammalian hosts. However, mammalian MXRA8 does not bind to alphaviruses that infect …

Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) are
promising molecules for therapeutic or prophylactic interventions. Beyond neutralization …