Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a
significant assembly motif for the development of new drug entities. Quinoline and its …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Quinoline or 1-aza-naphthalene is a weak tertiary base. Quinoline ring has been found to
possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

A convenient approach to antimalarial drug discovery is the use of the organic scaffold of a
known antimalarial drug and an organometallic moiety to alter its unwanted properties …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …

A new class of 4-aminoquinoline derivatives based on the natural product isatin scaffold
were designed and synthesized for biological evaluation against three strains of the malaria …

Parasitic diseases represent a major world health problem with very limited therapeutic
options, most of the available treatments being decades old and suffering from limited …

A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …