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Therapeutic glucocorticoids: mechanisms of actions in rheumatic diseases
Therapeutic glucocorticoids have been widely used in rheumatic diseases since they
became available over 60 years ago. Despite the advent of more specific biologic therapies …
became available over 60 years ago. Despite the advent of more specific biologic therapies …
The role of glucocorticoids in inflammatory diseases
For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a …
treatment option for inflammatory diseases. However, their benefits do not come without a …
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
Glucocorticoids (GCs) are widely used in tumor therapy to reduce tumor growth,
inflammation, edema, and other side effects. Controversially, GCs may also cause the …
inflammation, edema, and other side effects. Controversially, GCs may also cause the …
Epigenetic mechanisms of the glucocorticoid receptor
The glucocorticoid receptor (GR) has been shown to be important for mediating cellular
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional …
Role of microRNAs in immune regulation with translational and clinical applications
MicroRNAs (miRNAs) are 19–23 nucleotide long, evolutionarily conserved noncoding RNA
molecules that regulate gene expression at the post-transcriptional level. In this review …
molecules that regulate gene expression at the post-transcriptional level. In this review …
Extracellular vesicle miRNAs drive aberrant macrophage responses in NSAID‐exacerbated respiratory disease
Abstract Background Extracellular vesicles (EVs) have been implicated in the pathogenesis
of asthma, however, how EVs contribute to immune dysfunction and type 2 airway …
of asthma, however, how EVs contribute to immune dysfunction and type 2 airway …
Maternally derived low glucocorticoid mediates adrenal developmental programming alteration in offspring induced by dexamethasone
Y Chen, X **a, M Fang, G Chen, J Cao, H Qu… - Science of The Total …, 2021 - Elsevier
Adverse environments during pregnancy can increase susceptibility to chronic diseases in
adult offspring. The occurrence and development of fetal-originated diseases were …
adult offspring. The occurrence and development of fetal-originated diseases were …
[HTML][HTML] Acquired glucocorticoid resistance due to homologous glucocorticoid receptor downregulation: a modern look at an age-old problem
For over 70 years, the unique anti-inflammatory properties of glucocorticoids (GCs), which
mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor …
mediate their effects via the ligand-activated transcription factor, the glucocorticoid receptor …
MiR-133a-3p/Sirt1 epigenetic programming mediates hypercholesterolemia susceptibility in female offspring induced by prenatal dexamethasone exposure
X Li, W Hu, L Li, Z Chen, T Jiang, D Zhang, K Liu… - Biochemical …, 2022 - Elsevier
Mounting evidence indicates that adverse intrauterine conditions increase offspring's
hypercholesterolemia susceptibility in adulthood. This study aimed to confirm prenatal …
hypercholesterolemia susceptibility in adulthood. This study aimed to confirm prenatal …
miRNAs as modern biomarkers in asthma therapy
N Kierbiedź-Guzik, B Sozańska - International Journal of Molecular …, 2023 - mdpi.com
Asthma is a chronic inflammatory disease of the airways characterized by shortness of
breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 …
breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 …